Evolution of organelle-associated protein profiling
نویسندگان
چکیده
منابع مشابه
A Mammalian Organelle Map by Protein Correlation Profiling
Protein localization to membrane-enclosed organelles is a central feature of cellular organization. Using protein correlation profiling, we have mapped 1,404 proteins to ten subcellular locations in mouse liver, and these correspond with enzymatic assays, marker protein profiles, and confocal microscopy. These localizations allowed assessment of the specificity in published organellar proteomic...
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INTRODUCTION ........................................................... 208 ORGANELLE GENOME SIZE AND SHAPE ........................................ 208 Size and Shape of Mitochondrial Deoxyribonucleic Acids (DNAs) ...... ............... 209 Size and Shape of Chloroplast DNAs.............................................. 212 GENE ARRANGEMENT IN ORGANELLE DNAs ......... ...........................
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Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria, and nuclei) in six organs (brain, heart, kidn...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2009
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2008.11.017